Vertex Q2 2022 Earnings: Betting Big On Quality Over Quantity (NASDAQ:VRTX)



After a disappointing 2021, which included stopping work on a promising rare disease candidate, Vertex Pharmaceuticals (NASDAQ:VRTX) buyers are having fun with a 24% YTD return and a stellar Q2 earnings report because the blue chip’s distinctive enterprise mannequin proves it could work.


Quality over amount is one of the simplest ways to explain Vertex’s pipeline. Despite not having a deep portfolio of remedies, they dominate the markets they’re in.

Based on a $9.8B valuation of the cystic fibrosis (CF) market, Vertex has steadily managed ~80% of it over the previous few years by way of their 4 authorised CTFR modulators.

Vertex Cystic Fibrosis drug

Vertex Q2 2022 Earnings

Trikafta, often known as Kaftrio in Europe, is the latest of the bunch, spearheading the corporate’s development profile. The triple mixture remedy has put collectively 4 straight quarters of fifty%+ development which explains administration has been in a position to take pleasure in 20%+ general income development in every of these quarters, together with 23% in Q2.

Trikafta quarterly revenue and growth

Author, Vertex Earning Reports

We see comparable potential in Vertex’s future launches. Its sickle cell illness (SC) and beta thalassemia (TDT) drug, CTX001, in partnership with CRISPR Therapeutics (CRSP) is in section 3 trials with regulatory filings coming in late 2022.

Vertex CTX001 drug

Vertex Q2 2022 Earnings

Results at every stage have been promising as June data showed 100% efficacy in opposition to extreme SCD and 95% efficacy in opposition to TDT, offering hope that this collaboration could possibly be a one-time treatment.

This information solidifies Vertex’s $11B valuation on CTX001, particularly as a result of there are not any rivals within the market. The firm may doubtlessly have two blockbuster medicine, each having unparalleled development and a monopoly over the illness they deal with, all within the subsequent 2 years.

With a nearly assured income stream, they will even fund different promising tasks like their APOL1 kidney illness drug known as VX-147.

Vertex VX-147 drug

Vertex Q2 2022 Earnings

In section 2 trials, the treatment showed a 47.6% reduction in urine protein to creatine ratio, crushing analyst estimates of 30-40%. And a June 2026 estimated study completion date means Vertex may get a third main drug coming as quickly as late 2027. Keeping with the theme, it is because VX-147 is the first investigational therapy of its sort having zero future rivals.

Valuation Metrics

Cash stream protection is an effective way to measure the monetary energy of biotech firms. Because FDA trial and approval course of can take years, corporations can get locked up in decade-long partnerships, accumulating debt on the stability sheet for merchandise that have not even offered a dime. So working money flows operating by way of the corporate ought to be capable to cowl debt always.

Cash flow coverage of leading biotech companies

Author, Stock Analysis, MarketWatch

Vertex leads its friends on this class, reflecting long-term monetary energy. Its debt-to-equity ratio of 0.08 can be among the many trade’s finest and showcases the maturity of not having to enter debt markets to finance remedies within the pipeline.

Beyond the robust stability sheet, Vertex is buying and selling at a particularly undervalued share value. Despite having a PEG ratio simply north of two, which suggests the market expects double the projected earnings development to maintain present costs, we imagine future launches have not been factored in but.

The potential to have a complete of three multibillion-dollar medicine (CF, CTX001, VX-147) inside the subsequent 5-6 years not solely justifies the stock’s present valuation however leads us to imagine there’s extra room to go.


One apparent crimson flag is how concentrated the corporate is on CF merchandise. Everything from R&D to returning shareholder worth hinges upon the success of these authorised remedies.

Although one other main drug may are available about 2 years, that is nonetheless 8 quarters with none income diversification. If development declines or one thing worse occurs, a pricey trickle-down impact could be seen in each a part of the enterprise, hitting Vertex’s pipeline the toughest.

However, with income leaping over 20% in every of the previous 4 quarters and Trikafta displaying no indicators of slowing down, every part must be advantageous till CTX001 hopefully will get authorised.

Compounding issues, like competitors taking away market share, also needs to be mitigated as Vertex has grown its presence within the CF house yearly, a development that ought to proceed as AbbVie (ABBV) discontinued its work on a Trikafta competitor earlier this 12 months.

Another obtrusive situation is that the pipeline just isn’t as deep as different biotechs. Looking at a Regeneron (REGN) or a Gilead (GLD), you see lists of remedies in section 3 trials or being filed with the FDA, one thing that’s visibly lacking in Vertex’s portfolio.

But what the corporate lacks in amount, it makes up in high quality with 2 vital medicine on the way in which and over $8.2B in money to accumulate different corporations, because it just lately did with ViaCyte to bolster their Type 1 Diabetes (T1D) program, leaving us to imagine that will probably be simply advantageous.


By putting its belief in established merchandise and powerful money flows, Vertex has averted being flushed out like different speculative friends. The predictable development trajectory and approach it dominates particular illness markets present a stage of certainty within the firm and an immense quantity of confidence in its stock.

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